#PHTwitJC 8: Economic evaluation of HPV vaccination in UK

V#PHTwitJC will discuss the following paper on Sunday 18th December

M Jit et al (2008) Economic evaluation of human papillomavirus vaccination in the United Kingdom  British Medical Journal, 337:a769

Why is this area of public health important?

  • Human papillomaviruses (HPV) are responsible for nearly 3000 cases of cervical cancer and more than 100,000 diagnosed cases of anogenital warts in the United Kingdom every year
  • HPV vaccination could decrease the incidence (new cases) of cervical and other cancers and anogenital warts.

How does this study add to our knowledge?

  • This study assessed the cost effectiveness of routine vaccination of 12 year old schoolgirls against HPV infection in the United Kingdom.
  • It found that routine vaccination of girls aged 12 combined with an initial catch-up campaign up to age 18 is likely to be cost effective.
  • Vaccination of boys is unlikely to be cost effective.
  • A vaccine against HPV types 16 and 18 costing £13-£21 less per dose (depending on duration of vaccine protection) would be as cost effective as a vaccine against virus types 6, 11, 16, and 18

Discussion Points for Sunday 18th December @ 8pm:

  1. Were the aims of this study clear?
  2. Were the parameters used in the economic model clear, relevant and valid?
  3. Are the findings justifiable considering the information inputted into the models?
  4. Could anything else explain the results (chance, bias, confounders?)
  5. What implications do the findings have for public health practice & policy?
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